THE visionaries

Plato’s CAVETM was developed under the professional guidance and leadership of Dr. Brian Butler, M.D., Chairman, Professor and Medical Director for the Department of Radiation Oncology within The Methodist Hospital System. It is through his insight and guidance, and that of a dedicated team of medical experts and business professionals that Plato’s CAVETM has transformed from the ‘idea’ of advanced and intelligent medical imaging to the reality it is today.


Dr. Brian Butler, M.D.

Senior Member, The Methodist Hospital Research Institute Chair, Department of Radiation Oncology, The Methodist Hospital Clinical Professor of Radiation Oncology, Weill Cornell Medical College of Cornell University. After completing his postdoctoral training in 1987, Dr. Butler returned to the Wilford Hall USAF Medical Center in San Antonio, Texas where he became both the Chief of Radiation Oncology and the Chief of Brachytherapy. He also joined the faculty at The University of Texas Health Science Center at San Antonio as a Clinical Assistant Professor that same year. Dr. Butler would later join the Baylor College of Medicine where he would eventually become a full professor and the Chief of Radiation Oncology for both the medical school and the VA Hospital. He became the Medical Director of Radiation Oncology at Methodist in 1991, and received his faculty appointment at the Weill Medical School in 2006. Dr. Butler’s research centers on preclinical and clinical studies that combine radiation therapy and gene therapy for the treatment of prostate cancer. In recent years, he has extended these successful studies to other cancers, notably pancreatic cancer. His research interests also include 3-dimensional reconstruction of body organs to assist in better localization of radiation therapy.

Recent Publications

Hui Z, Tretiakova M, Zhang Z, Li Y, Wang X, Zhu JX, Gao Y, Mai W, Furge K, Qian CN, Amato R, Butler EB, Teh BT, Teh BS. Radiosensitization by inhibiting STAT1 in renal cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):288-95. Jhaveri P, Teh BS, Bloch C, Amato R, Butler EB, Paulino AC. Stereotactic body radiotherapy in the management of painful bone metastases. Oncology (Williston Park). 2008 Jun;22(7):782-8; discussion 788-9, 796-7. Review. Teh BS, Bastasch MD, Mai WY, Kadmon D, Miles BJ, Butler EB. Preliminary report of the effect of high-dose adjuvant intensity modulated radiation therapy on the sural nerve graft for cavernosal nerve sacrifice after radical prostatectomy. Am J Clin Oncol. 2007 Aug;30(4):395-400. Teh BS, Paulino AC, Lu HH, Chiu JK, Richardson S, Chiang S, Amato R, Butler EB, Bloch C. Versatility of the Novalis system to deliver image-guided stereotactic body radiation therapy (SBRT) for various anatomical sites. Technol Cancer Res Treat. 2007 Aug;6(4):347-54. Teh BS, Bloch C, Paulino AC, Shen S, Hinckley L, Baskin D, Butler EB, Amato R. Pathologic complete response in renal cell carcinoma brain metastases treated with stereotactic radiosurgery. Clin Genitourin Cancer. 2007 Jun;5(5):334-7. Butler EB, Shukla V, Paulino AC, Lu HH, Butler R, Smiedala M, Kurk J, Grant WH 3rd, McGary JE, Teh BS. Computer visualization techniques (CVTs) foster evidence-based target delineation. Cancer Invest. 2007 Feb;25(1):1-5.


John Hoff Ph.D.

President & CEO

Mr. Hoff is the President and Chief Executive Officer for Facts & Figures LLC and MyView LLC. During the span of his career Mr. Hoff has 50 years of combined global research, executive, financial and operational experience. He has been a senior executive to several prominent companies and has served as advisor to national governments and led investment missions to 18 countries. Mr. Hoff also has served on the boards of several companies in the Middle East and Latin America as well as on the Board and Investment Committee of the Boyce Thompson Institute for Research, the Board and Executive Committee of the Agribusiness Council of New York and on the Board of the LaRuta Maya Foundation. Additionally, Mr. Hoff served three terms on the Cornell Council; was moderator, “Being the Best Overseas”, at the First Entrepreneur of the Year Symposium, Johnson Graduate School of Management, Cornell University; was on the Board of a major national bank and an active trustee for King Ranch heirs. Mr. Hoff earned a Ph.D. from Cornell University in Life Sciences.


Jennifer L. Hoff B.S

Director and Manager

With a B.S in agribusiness, economics, and real state from Cornell University, Jennifer has extensive experience in asset management and marketing. Along with her interest in Plato’s CAVETM, Jennifer Hoff is currently Senior Vice President, IBC Bank, responsible for its portfolio and bank owned commercial real estate assets with a combined value in excess of $350MM, as well President and owner of the Seville Group and Hoff Luxury Estates. The Seville Group provides a consulting, marketing and investment function to the overall business. It operates on a project basis.

Recent Publications

Country Properties, ISBN 0-9664193-0-8, Certificate of Merit, Writer’s Digest 1999


Brant Lipscomb M.D.

A prominent 2nd generation orthopedic surgeon, Dr. Lipscomb and his family are close friends of both John and Jennifer Hoff. The Lipscomb name is well known in the medical industry as his father developed the tool called the “LIPSCOMB tool” for arthroscopic knee surgery. He also was the team physician for the Vanderbilt University football team for decades and a multitude of buildings in Nashville carry his name. In addition, he has well respected Foundations involving medical related activities. Dr. Lipscomb specializes in the shoulder and knee, is internationally known, and has treated many high profile athletes. Dr. A Brant Lipscomb, M.D. is an Assistant professor in the Department of Orthopedic Surgery at The University of Texas Medical School at Houston specializing in sports medicine with special interests including shoulder and knee injuries treated both arthroscopically and with open procedures.


In addition to the visionaries behind Plato’s CAVETM, the program has an Advisory Council with a wide array of medical professionals, administrators and business executives.